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This study describes socialdemographic features and perinatal outcome in pregnancies with major fetal malformation diagnosed antenatally. This information is useful for parent counselingin cases with an abnormal fetal diagnosis.
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What is the leading cause of infant mortality? A note on the interpretation of official statistics. Am J Public Health. An evaluation of Congenital malformations surveillance in New York State: Rev Assoc Med Bras.
J Gynecol Obstet Biol Reprod. Environmental and occupational exposures. Reproductive risks and prenatal diagnosis. Appleton and Lange; Detection of fetal structural abnormalities at the week ultrasound scan. Congenital malformations in Rio de Janeiro, Brazil: Cytogenotoxic effects of J. It includes different kinds and numbers of chromosomal aberrations in the root tip meristematic cells.
Among the chromosomal alterations observed in anaphase-telophase cells in this study, we highlight the presence of bridges, chromosomes and laggards.
Nevertheless, the most frequent alterations were observed in metaphase: These dose-independent changes were observed at all concentrations of the oil Table II. The presence of sticky chromosomes reflects the genotoxic effects ofJ. This change is irreversible and generally leads to cell death. The occurrence of strongly stained nuclei throughout this study, characterized as condensed nuclei, is also an alteration of the normal structure of the nuclei. Nuclear condensation is a feature that is associated with the process of programmed cell death Andrade et al.
These data demonstrate the toxic action of the J. Another alteration commonly observed in treated cells was c-metaphase, which got this name based on the observation of chromosomes around the equator of the cell in a manner similar to that seen in cells treated with colchicine.
The observation of c-metaphase cells indicates the action of the toxic agent on the spindle fibers, preventing the continuation of the mitotic cycle Leme and Marin-Morales Both sticky chromosomes and c-metaphase cells are abnormalities that characterize the aneugenic action of the components of the J. Nuclear alterations condensed nuclei and micronucleated cells were also observed and the percentage of cells with such alterations increased significantly for the different treatments.
As stated earlier, nuclear changes, such as chromatin condensation, indicate that cells undergo programmed cell death Andrade-Vieira et al.
The interaction of PEs with DNA and other cellular components can activate the molecular machinery, leading to cell death. Other nuclear alterations observed in this study were micronuclei, which probably arose from both clastogenic and aneugenic actions of the J.
Considering the high frequency of cells arising from the aneugenic action of J. The toxicity of J.
Effects of Jatropha curcas oil inLactuca sativa root tip bioassays
The goals of such bioassays lie in the interests of using the plant seed for biodiesel production and in animal nutrition, and hence, in making its use more economically viable. However, the presence of toxic compounds in the cake can lead to death of the animals, depending on the amount of seed used. Acute doses of 2. These authors demonstrated increased mortality with increasing concentrations of PEs in all the bioassays tested, with EC50 48 h values of 0.
Among the bacterial species tested, Streptococcus pyogenes andProteus mirabilis were highly susceptible with a minimum inhibitory concentration of mgL—1 of PEs. Regardless of the treatment, all rats showed reduced appetite and diet intake was low, accompanied by diarrhea. The rats also exhibited reduced motor activity.
However, the rats fed with treated meal exhibited delayed mortality when compared to rats fed untreated meal. The present study is the first one to use a plant bioassay to test the toxicity of J. It has been demonstrated that J. In addition, the tests applied have shown reproducibility, an important quality to verify the quality of detoxification and the determination of toxic doses, protecting animals from direct exposure to this test, and hence, avoiding their death.
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The effect of cyanide compounds, fluorides, aluminum, and inorganic oxides present in spent pot liner on germination and root tip cells of Lactuca sativa. Ecotox Environ Saf The Allium test - a simple, eukaryote genotoxicity assay. Am Biol Teach Have I just flashed my knickers. As always, dw, you are only as safe as you want to be on a dating app: They settled the dispute out of court last year.
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